adaptTest asd bcrm blockrand clinfun clinsig coin conf.design cosa CRM ctrdata dfcrm dfped DTAT epibasix ewoc experiment FrF2 HH Hmisc ldbounds longpower MCPMod meta metafor metaLik metasens MinEDfind multcomp nppbib PowerTOST PowerUpR pwr randomizeR replicateBE rmeta samplesize simglm speff2trial ssanv TEQR ThreeGroups TrialSize UnifiedDoseFinding